MERS-CoV‒specific T-Cell responses in camels after single MVA-MERS-S vaccination

Meyer Zu Natrup, Christian; Schünemann, Lisa-Marie; Saletti, Giulietta; Clever, Sabrina; Herder, Vanessa; Joseph, Sunitha; Rodriguez, Marina; Wernery, Ulrich; Sutter, Gerd; Volz, Asisa

doi:10.3201/eid2906.230128

Article / Chapter 2023 CC BY 4.0

Published

MERS-CoV‒specific T-Cell responses in camels after single MVA-MERS-S vaccination

Meyer zu Natrup, Christian ; Schünemann, Lisa-Marie ; Saletti, Giulietta ; Clever, Sabrina ; Herder, Vanessa; Joseph, Sunitha; Rodriguez, Marina; Wernery, Ulrich; Sutter, Gerd ; Volz, Asisa

We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.