Stiftung Tierärztliche Hochschule Hannover (TiHo)TiHo eLib

Teach an old dog new tricks : meningoencephalitis of unknown origin (MUO) in Australian shepherd dogs

Meningoencephalitis of unknown origin is mostly considered a disease of young smalldogs and terrier breeds, while older dogs presenting with clinical signs of deteriorat-ing encephalopathy are more commonly diagnosed with intracranial neoplasia. In thiscase series, three Australian shepherd dogs, 7, 10 and 11 years old, were diagnosed withmeningoencephalitis of unknown origin; with serial magnetic resonance imaging in twodogs and postmortem examination in one dog. Follow-up magnetic resonance imagingexamination after 4 months showed complete resolution of magnetic resonance imagingabnormalities in one dog treated with prednisolone. The other dog had a recurrence ofclinical signs and multifocal de novo lesions noted in magnetic resonance imaging doneat 23 months after diagnosis and tapering of prednisolone. In older dogs, a diagnosisof intracranial neoplasia should not be assumed based on clinical signs of deterioratingencephalopathy alone, and meningoencephalitis of unknown origin should be on thedifferential list. Older dogs diagnosed with meningoencephalitis of unknown origin canhave good outcomes with immunomodulatory therapy.


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