Stiftung Tierärztliche Hochschule Hannover (TiHo)TiHo eLib

Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection

Lawsonia (L.) intracellularis is a widespread, economically important bacterium
causing the porcine proliferative enteropathy (PPE). In this study, we evaluated
intestinal microbiota of naturally exposed L. intracellularis-positive pigs
under standardized conditions. To obtain three independent repetitions, 27
L. intracellularis-infected pigs (19.0 ± 1.50 kg body weight) fromone farmwere
divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs
were either vaccinated against L. intracellularis via oral drenching on their 21st
day of life (attenuated live vaccine) or non-vaccinated and selected according
to clinical findings (pigs without deviating fecal consistency or with moderate
to soft fecal consistency). Comparison of the clinically inconspicuous piglets
that di��ered regarding their vaccination status showed fewer significant
di��erences in fecal microbiota composition. The vaccination led to an overall
enrichment of bacterial species belonging to the order Clostridiales, while
species of the genus Collinsella and Prevotella were decreased. Several
bacterial species belonging to the order Bacteroidales, mainly of the family
Prevotellacecae, often closely matching Prevotella copri di��ered significantly
between non-vaccinated clinically inconspicuous and conspicuous piglets.
Whether those bacterial species play a role in mitigating the severity of an
L. intracellularis infection remains to be defined.

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