Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Zickler, Martin; Stanelle-Bertram, Stephanie; Ehret, Sandra; Heinrich, Fabian; Lange, Philine; Schaumburg, Berfin; Kouassi, Nancy, Mounogou; Beck, Sebastian; Jaeckstein, Michelle, Y.; Mann, Oliver; Krasemann, Susanne; Schroeder, Maria; Jarczak, Dominik; Nierhaus, Axel; Kluge, Stefan; Peschka, Manuela; Schlüter, Hartmut; Renné, Thomas; Pueschel, Klaus; Kloetgen, Andreas; Scheja, Ludger; Ondruschka, Benjamin; Heeren, Joerg; Gabriel, Guelsah

doi:10.1016/j.cmet.2021.12.002

Published

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.