Stiftung Tierärztliche Hochschule Hannover (TiHo)

Serologic prevalence of Ebola virus in Equatorial Africa

Steffen, Imke; Lu, Kai; Yamamoto, Lauren K.; Hoff, Nicole A.; Mulembakani, Prime; Wemakoy, Emile O.; Muyembe-Tamfum, Jean-Jacques; Ndembi, Nicaise; Brennan, Catherine A.; Hackett, John Jr.; Stramer, Susan L.; Switzer, William M.; Saragosti, Sentob; Mbensa, Guy O.; Laperche, Syria; Rimoin, Anne W.; Simmons, Graham

We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.

Cite

Citation style:
Could not load citation form.

Rights

Use and reproduction:
All rights reserved

Export