Stiftung Tierärztliche Hochschule Hannover (TiHo)

Scent dog identification of samples from COVID-19 patients : a pilot study

Jendrny, Paula; Schulz, Claudia ORCID; Twele, Friederike GND; Meller, Sebastian ORCID; von Köckritz-Blickwede, Maren; Osterhaus, Albertus Dominicus Marcellinus Erasmus GND; Ebbers, Janek; Pilchová, Veronika; Pink, Isabell; Welte, Tobias; Manns, Michael Peter; Fathi, Anahita; Ernst, Christiane; Addo, Marylyn Martina; Schalke, Esther; Volk, Holger Andreas ORCID

BACKGROUND:As the COVID-19 pandemic continues to spread, early, ideally real-time, identification of SARS-CoV-2 infected individuals is pivotal in interrupting infection chains. Volatile organic compounds produced during respiratory infections can cause specific scent imprints, which can be detected by trained dogs with a high rate of precision. METHODS:Eight detection dogs were trained for 1 week to detect saliva or tracheobronchial secretions of SARS-CoV-2 infected patients in a randomised, double-blinded and controlled study. RESULTS:The dogs were able to discriminate between samples of infected (positive) and non-infected (negative) individuals with average diagnostic sensitivity of 82.63% (95% confidence interval [CI]: 82.02-83.24%) and specificity of 96.35% (95% CI: 96.31-96.39%). During the presentation of 1012 randomised samples, the dogs achieved an overall average detection rate of 94% (±3.4%) with 157 correct indications of positive, 792 correct rejections of negative, 33 incorrect indications of negative or incorrect rejections of 30 positive sample presentations. CONCLUSIONS:These preliminary findings indicate that trained detection dogs can identify respiratory secretion samples from hospitalised and clinically diseased SARS-CoV-2 infected individuals by discriminating between samples from SARS-CoV-2 infected patients and negative controls. This data may form the basis for the reliable screening method of SARS-CoV-2 infected people.

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Jendrny, P., Schulz, C., Twele, F., Meller, S., von Köckritz-Blickwede, M., Osterhaus, A.D.M.E., Ebbers, J., Pilchová, V., Pink, I., Welte, T., Manns, M.P., Fathi, A., Ernst, C., Addo, M.M., Schalke, E., Volk, H.A., 2020. Scent dog identification of samples from COVID-19 patients: a pilot study. BMC infectious diseases 20, 536. https://doi.org/10.1186/s12879-020-05281-3
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