Stiftung Tierärztliche Hochschule Hannover (TiHo)

A structural UGDH variant associated with standard Munchkin cats

Struck, Ann-Kathrin ORCID; Braun, Marina; Detering, Kim Aline; Dziallas, Peter; Neßler, Jasmin GND; Fehr, Michael GND; Metzger, Julia ORCID; Distl, Ottmar GND

BACKGROUND:Munchkin cats were founded on a naturally occurring mutation segregating into long-legged and short-legged types. Short-legged cats showed disproportionate dwarfism (chondrodysplasia) in which all four legs are short and are referred as standard Munchkin cats. Long-legged animals are referred as non-standard Munchkin cats. A previous study using genome-wide single nucleotide polymorphisms (SNPs) for genome-wide association analysis identified a significantly associated region at 168-184 Mb on feline chromosome (FCA) B1. RESULTS:In this study, we validated the critical region on FCA B1 using a case-control study with 89 cats and 14 FCA B1-SNPs. A structural variant within UGDH (NC_018726.2:g.173294289_173297592delins108, Felis catus 8.0, equivalent to NC_018726.3:g.174882895_174886198delins108, Felis catus 9.0) on FCA B1 was perfectly associated with the phenotype of short-legged standard Munchkin cats. CONCLUSION:This UGDH structural variant very likely causes the chondrodysplastic (standard) phenotype in Munchkin cats. The lack of homozygous mutant phenotypes and reduced litter sizes in standard Munchkin cats suggest an autosomal recessive lethal trait in the homozygote state. We propose an autosomal dominant mode of inheritance for the chondrodysplastic condition in Munchkin cats.

Cite

Citation style:
Struck, A.-K., Braun, M., Detering, K.A., Dziallas, P., Neßler, J., Fehr, M., Metzger, J., Distl, O., 2020. A structural UGDH variant associated with standard Munchkin cats. BMC genetics 21, 67. https://doi.org/10.1186/s12863-020-00875-x
Could not load citation form. Default citation form is displayed.

Rights

Use and reproduction:

Export