Stiftung Tierärztliche Hochschule Hannover (TiHo)

Meningioma and associated cerebral infarction in three dogs

Frank, Lisa; Burigk, Laura; Lehmbecker, Annika GND; Wohlsein, Peter ORCID; Schütter, Alexandra GND; Meyerhoff, Nina; Tipold, Andrea GND; Nessler, Jasmin GND

BACKGROUND:In dogs, meningiomas mostly cause chronic progressive clinical signs due to slow tumor growth. CASE PRESENTATION:In contrast, three dogs were presented with the history of chronic generalized tonic-clonic seizures and peracute deterioration with sudden onset of neurological deficits in accordance with an extensive unilateral forebrain lesion. Magnetic resonance imaging examinations of the dogs revealed a well-delineated extraaxial T2W hyperintense mass in the rostral forebrain with homogeneous contrast enhancement. Additionally, an intraaxial, well-demarcated, unilateral lesion was apparent in the parenchyma supplied by the middle cerebral artery. In two cases, necropsy revealed meningothelial meningioma in the rostral fossa and marked eosinophilic neuronal necrosis, a sign of ischemia, focal malacia, edema and gliosis in the temporal lobe and hippocampus because of a focal thrombosis of the middle cerebral artery. In the third case symptomatic treatment resulted in improvement of clinical signs enabling a good quality of life for the patient. CONCLUSIONS:In dogs with structural epilepsy caused by meningioma, acute deterioration of clinical signs can be associated with ischemic infarctions as a potential complication.

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Frank, L., Burigk, L., Lehmbecker, A., Wohlsein, P., Schütter, A., Meyerhoff, N., Tipold, A., Nessler, J., 2020. Meningioma and associated cerebral infarction in three dogs. BMC veterinary research 16: 177. https://doi.org/10.1186/s12917-020-02388-2
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