Stiftung Tierärztliche Hochschule Hannover (TiHo)

Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation

Fenn, Joe ORCID; Ru, Hongyu; Jeffery, Nick D; Moore, Sarah ORCID; Tipold, Andrea GND; Meyer-Almes, Franz-Josef GND; Wang-Leandro, Adriano ORCID; Mariani, Christopher L. ORCID; Early, Peter J. ORCID; Muñana, Karen R. ORCID; Olby, Natasha J. ORCID

BACKGROUND:Retrospective research recently identified a possible relationship between duration of surgery and outcome in severely affected dogs treated surgically for acute thoracolumbar intervertebral disk herniation (TL-IVDH). HYPOTHESIS:That increased duration of surgery is associated with poorer outcome in dogs with absent pain perception treated surgically for TL-IVDH. ANIMALS:Two hundred ninety-seven paraplegic dogs with absent pain perception surgically treated for acute TL-IVDH. METHODS:Retrospective cohort study. Medical records of 5 institutions were reviewed. Inclusion criteria were paraplegia with absence of pain perception, surgical treatment of TL-IVDH, and 1-year postoperative outcome (ambulatory: yes or no). Canine data, outcome, and surgery and total anesthesia duration were retrieved. RESULTS:In this study, 183/297 (61.6%) dogs were ambulatory within 1 year, 114 (38.4%) dogs failed to recover, including 74 dogs (24.9%) euthanized because of progressive myelomalacia. Median anesthesia duration in dogs that regained ambulation within 1 year of surgery (4.0 hours, interquartile range [IQR] 3.2-5.1) was significantly shorter than those that did not (4.5 hours, IQR 3.7-5.6, P = .01). Multivariable logistic regression demonstrated a significant negative association between both duration of surgery and total anesthesia time and ambulation at 1 year when controlling for body weight and number of disk spaces operated on. CONCLUSIONS AND CLINICAL IMPORTANCE:Findings support a negative association between increased duration of anesthesia and outcome in this group of dogs. However, the retrospective nature of the data does not imply a causal relationship.

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Fenn, J., Ru, H., Jeffery, N.D., Moore, S., Tipold, A., Soebbeler, F.J., Wang-Leandro, A., Mariani, C.L., Early, P.J., Muñana, K.R., Olby, N.J., 2020. Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation. Journal of veterinary internal medicine 34, 1507–1513. https://doi.org/10.1111/jvim.15796
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