Stiftung Tierärztliche Hochschule Hannover (TiHo)

A vaccinology approach to the identification and characterization of Dermanyssus gallinae candidate protective antigens for the control of poultry red mite infestations

Lima-Barbero, José Francisco ORCID; Contreras, Marinela; Mateos-Hernández, Lourdes ORCID; Mata-Lorenzo, Francisco Manuel; Triguero-Ocaña, Roxana; Sparagano, Olivier ORCID; Finn, Robert D ORCID; Strube, Christina; Price, Daniel R G; Nunn, Francesca; Bartley, Kathryn; Höfle, Ursula; Boadella, Mariana; Nisbet, Alasdair J; Fuente, José de la; Villar, Margarita; de la Fuente, José

The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.

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Lima-Barbero, J.F., Contreras, M., Mateos-Hernández, L., Mata-Lorenzo, F.M., Triguero-Ocaña, R., Sparagano, O., Finn, R.D., Strube, C., Price, D.R.G., Nunn, F., Bartley, K., Höfle, U., Boadella, M., Nisbet, A.J., de la Fuente, J., Villar, M., de la Fuente, J., 2019. A vaccinology approach to the identification and characterization of Dermanyssus gallinae candidate protective antigens for the control of poultry red mite infestations. Vaccines 7. https://doi.org/10.3390/vaccines7040190
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