Stiftung Tierärztliche Hochschule Hannover (TiHo)

High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany

Affiliation
Georg-August-University, Goettingen, Germany.
Hisgen, Linda;
Affiliation
German Primate Center, Goettingen, Germany.
Abel, Lena;
Affiliation
German Primate Center, Goettingen, Germany.
Hallmaier-Wacker, Luisa K.;
Affiliation
German Primate Center, Goettingen, Germany.
Lueert, Simone;
GND
133523055
ORCID
0000-0002-2556-3948
Affiliation
University of Veterinary Medicine Hanover - Foundation, Hanover, Germany.
Siebert, Ursula;
Affiliation
University of Veterinary Medicine Hanover - Foundation, Hanover, Germany.
Fähndrich, Marcus;
GND
173105785
Affiliation
University of Veterinary Medicine Hanover - Foundation, Hanover, Germany.
Strauß, Egbert;
Affiliation
University of Veterinary Medicine Hanover - Foundation, Hanover, Germany.
Voigt, Ulrich;
Affiliation
Masaryk University, Brno, Czech Republic.
Nováková, Markéta;
Affiliation
Masaryk University, Brno, Czech Republic.
Šmajs, David;
ORCID
0000-0001-5744-4946
Affiliation
Georg-August-University, Goettingen, Germany.
Knauf, Sascha

The lagomorph infecting Treponema paraluisleporidarum is a close relative of the human syphilis-bacterium Treponema pallidum. There is a paucity of information on the epidemiology of hare syphilis and its relationship to the rabbit- and human-infecting treponemes that cause syphilis. In our study, we tested 734 serum samples from European brown hares (Lepus europaeus) collected between 2007 and 2019 in the federal state of Lower Saxony, Germany, for the presence of antibodies against Treponema paraluisleporidarum. Since T. paraluisleporidarum cross-reacts with T. pallidum antigen, we used a commercially available Treponema pallidum particle agglutination (TPPA) to test for the presence of antibodies. A high seropositivity (n = 405/734) was detected. An additional 233 serum samples were retested using a fluorescent treponemal antibody absorption test to confirm the results of the TPPA assay. Our results show that infection is widespread in Lower Saxony and suggest a horizontal (sexual) transmission mode since adult hares show significantly higher seropositivity than juveniles (odds ratio: 0.03 [95% CI 0.02-0.05], p < .0001). No difference was detected based on gender (odds ratio: 0.79 [95% Cl 0.58-1.07], p = .1283). Further studies are warranted to genetically characterise the T. paraluisleporidarum strains that infect wild hares.

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