Stiftung Tierärztliche Hochschule Hannover (TiHo)

Rhodesian Ridgebacks have an increased risk to develop benign prostatic hyperplasia

Affiliation
Unit of Reproductive Medicine - Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Werhahn Beining, Franziska;
GND
140385991
ORCID
0000-0001-9861-637X
Affiliation
Unit of Reproductive Medicine - Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Urhausen, Carola;
GND
1029957681
Affiliation
Unit of Reproductive Medicine - Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Wolf, Karola;
GND
133948544
ORCID
0000-0001-7218-293X
Affiliation
Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany.
Schmicke, Marion;
Affiliation
Institute for Biometry, Epidemiology and Information, University of Veterinary Medicine Hannover, Hannover, Germany.
Rohn, Karl;
Affiliation
Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Schuler, Gerhard;
ORCID
0000-0003-1778-5978
Affiliation
Unit of Reproductive Medicine - Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Günzel-Apel, Anne-Rose

Benign prostatic hyperplasia (BPH) is an age-dependent primarily non-inflammatory enlargement of the accessory gland in the intact dog. The aim of the present study was to control a previously raised suspicion of a breed-related higher incidence of BPH in dogs of the Rhodesian Ridgeback breed. For this, 18 Labrador Retrievers/LR and 20 Rhodesian Ridgebacks/RR were assigned to the age groups 18-24 months (n = 12), 25-48 months (n = 13) and 49-72 months (n = 13). Prostate gland status was determined by rectal palpation, B-mode ultrasound, calculation of the prostate gland volume and semen analysis regarding haemospermia and was classified according to blood plasma concentrations of canine prostate-specific arginine esterase (CPSE) (normal ≤ 60 ng/ml, increased ≥ 61 ng/ml; Pinheiro et al., 2017). Concentrations of testosterone, 5α-dihydrotestosterone and estradiol were analysed in peripheral blood serum or plasma for detecting breed-specific conditions regarding the endocrine metabolism. Prostatic volume was significantly larger in RR irrespective of the CPSE status. In RR, BPH occurred more frequently and started at an earlier age compared with the LR. Breed-related specificities in steroid metabolism in the RR were indicated by correlations of 5α-dihydrotestosterone and estradiol with age and of testosterone with prostate gland volume. Although the incidence of sonographic signs of BPH and haemospermia did not fit with normal and increased CPSE concentrations, a breed-specific higher incidence of BPH in the RR breed could be clearly verified.

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