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Detrimental role of neutrophil extracellular traps during dengue virus infection

ORCID
0000-0003-4614-618X
Affiliation
Research Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany.
Schulz, Claudia;
GND
132226200
ORCID
0000-0003-0542-8033
Affiliation
Viral Zoonosis-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; Institute of Virology, University of Veterinary Medicine, Hannover, Germany.
Gabriel, Gülsah;
GND
129745138
ORCID
0000-0001-7712-9767
Affiliation
Research Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: mkoeckbl@tiho-hannover.de.
Köckritz-Blickwede, Maren von

A recent article by Sung et al. identified the CLEC2 platelet receptor as an important factor of lethal dengue virus infection. Formation of neutrophil extracellular traps via crosstalk with CLEC5A and TLR2 neutrophils were ascribed a causative role in DENV infection. This provides new insights for the development of candidate broad-spectrum therapies against hemorrhagic virus infections.

Category

Published in:
Trends in immunology
Vol. 41, No. 1 (2020), p. 3-6
Volume:
41
No.:
1
Date Issued:
2020
DOI:
10.1016/j.it.2019.11.010
Other identifier (pubmed):
31791719
Language:
English
Type of Resource:
Text
Keywords:
Dengue virus; Neutrophils; Influenza Virus; Platelets; Neutrophil Extracellular Traps
Anzeige in:
Research publications
Anzeige in:
TiHo bibliography
DDC subject of DNB:
630 Veterinary medicine & agriculture
Auswertung Publikationsindex:
2020
Link to Raw Object:
https://www.sciencedirect.com/science/article/pii/S1471490619302558?via%3Dihub
Hosting institution:
Institutes, Institute of Virology (Dept. of Infectious Diseases)
Hosting institution:
Institutes, Institute for Biochemistry
Hosting institution:
Research Centers, Research Center for Emerging Infections and Zoonoses (RIZ)

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