Stiftung Tierärztliche Hochschule Hannover (TiHo)

Detrimental role of neutrophil extracellular traps during dengue virus infection

ORCID
0000-0003-4614-618X
Affiliation
Research Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany.
Schulz, Claudia;
GND
132226200
ORCID
0000-0003-0542-8033
Affiliation
Viral Zoonosis-One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany; Institute of Virology, University of Veterinary Medicine, Hannover, Germany.
Gabriel, Gülsah;
GND
129745138
ORCID
0000-0001-7712-9767
Affiliation
Research Center for Emerging Infections and Zoonosis, University of Veterinary Medicine, Hannover, Germany; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: mkoeckbl@tiho-hannover.de.
von Köckritz-Blickwede, Maren

A recent article by Sung et al. identified the CLEC2 platelet receptor as an important factor of lethal dengue virus infection. Formation of neutrophil extracellular traps via crosstalk with CLEC5A and TLR2 neutrophils were ascribed a causative role in DENV infection. This provides new insights for the development of candidate broad-spectrum therapies against hemorrhagic virus infections.

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