Stiftung Tierärztliche Hochschule Hannover (TiHo)

Immune responses upon in ovo HVT-IBD vaccination vary between different chicken lines

Affiliation
Clinic for Poultry, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany. Electronic address: marina.dobner@tiho-hannover.de.
Dobner, Marina;
Affiliation
Clinic for Poultry, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany. Electronic address: monika.auerbach@tiho-hannover.de.
Auerbach, Monika;
Affiliation
Boehringer Ingelheim, Veterinary Research Center GmbH Co. KG, Bemeroderstr. 31, 30559, Hannover, Germany. Electronic address: egbert.mundt@boehringer-ingelheim.com.
Mundt, Egbert;
Affiliation
Lohmann Tierzucht GmbH, Am Seedeich 9-11, 27472, Cuxhaven, Germany. Electronic address: preisinger@ltz.de.
Preisinger, Rudolf;
Affiliation
Lohmann Tierzucht GmbH, Am Seedeich 9-11, 27472, Cuxhaven, Germany. Electronic address: icken@ltz.de.
Icken, Wiebke;
GND
1018821449
ORCID
0000-0002-8177-3755
Affiliation
Clinic for Poultry, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany. Electronic address: silke.rautenschlein@tiho-hannover.de.
Rautenschlein, Silke

The genotype of chickens is assumed to be associated with variable immune responses. In this study a modern, moderate performing dual-purpose chicken line (DT) was compared with a high-performing layer-type (LT) as well as a broiler-type (BT) chicken line. One group of each genotype was vaccinated in ovo with a recombinant herpesvirus of turkeys expressing the virus protein VP2 of the infectious bursal disease virus (HVT-IBD) while one group of each genotype was left HVT-IBD unvaccinated (control group). Genotype associated differences in innate and adapted immune responses between the groups were determined over five weeks post hatch. HVT-IBD vaccination significantly enhanced humoral immune responses against subsequently applied live vaccines compared to non-HVT-IBD vaccinated groups at some of the investigated time points (P < 0.05). In addition HVT-IBD vaccination had depending on the genotype a significant impact on splenic macrophage as well as bursal CD4+ T-cell numbers (P < 0.05). On the other hand, the detectable genotype influence on Interferon (IFN) γ and nitric oxide (NO) release of ex vivo stimulated spleen cells was independent of HVT-IBD vaccination. The results of our study suggest considering a genotype specific vaccination regime in the field.

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