Stiftung Tierärztliche Hochschule Hannover (TiHo)

To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz, Sebastian ORCID; Amini, Poorya; Anders, Hans-Joachim; Andrade, Felipe; Bilyy, Rostyslav; Chatfield, Simon; Cichon, Iwona; Clancy, Danielle M.; Desai, Jyaysi; Dumych, Tetiana; Dwivedi, Nishant; Gordon, Rachael Ann; Hahn, Jonas ORCID; Hidalgo, Andrés ORCID; Hoffmann, Markus H. ORCID; Kaplan, Mariana J.; Knight, Jason S.; Kolaczkowska, Elzbieta; Kubes, Paul; Leppkes, Moritz; Manfredi, Angelo A.; Martin, Seamus J. ORCID; Maueröder, Christian ORCID; Maugeri, Norma; Mitroulis, Ioannis; Munoz, Luis E.; Nakazawa, Daigo; Neeli, Indira; Nizet, Victor; Pieterse, Elmar; Radic, Marko Z.; Reinwald, Christiane; Ritis, Konstantinos; Rovere-Querini, Patrizia; Santocki, Michal; Schauer, Christine; Schett, Georg; Shlomchik, Mark Jay; Simon, Hans-Uwe ORCID; Skendros, Panagiotis; Stojkov, Darko; Vandenabeele, Peter ORCID; Berghe, Tom Vanden; van der Vlag, Johan; Vitkov, Ljubomir; von Köckritz-Blickwede, Maren GND; Yousefi, Shida ORCID; Zarbock, Alexander; Herrmann, Martin

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.


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Boeltz, Sebastian / Amini, Poorya / Anders, Hans-Joachim / et al: To NET or not to NET. current opinions and state of the science regarding the formation of neutrophil extracellular traps. 2019.

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