Stiftung Tierärztliche Hochschule Hannover (TiHo)

The vitamin E derivative gamma tocotrienol promotes anti-tumor effects in acute myeloid leukemia cell lines

Ghanem, Paola; Zouein, Annalise; Mohamad, Maya ORCID; Hodroj, Mohammad H. ORCID; Haykal, Tony; Abou Najem, Sonia; Naim, Hassan Y. GND; Rizk, Sandra

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.

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Ghanem, Paola / Zouein, Annalise / Mohamad, Maya / et al: The vitamin E derivative gamma tocotrienol promotes anti-tumor effects in acute myeloid leukemia cell lines. 2019.

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