Stiftung Tierärztliche Hochschule Hannover (TiHo)

Combination drug treatment prolongs survival of experimentally infected mice with silver-haired bat rabies virus

ORCID
0000-0002-7462-7303
Affiliation
Artemis One Health Research Foundation, Delft, The Netherlands; Erasmus Medical Centre Rotterdam, The Netherlands.
Martina, Byron;
Affiliation
Department of Virology, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100 Puławy, Poland.
Smreczak, Marcin;
GND
1025310977
Affiliation
Department of Virology, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100 Puławy, Poland.
Orłowska, Anna;
ORCID
0000-0002-0589-0714
Affiliation
Department of Virology, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100 Puławy, Poland.
Marzec, Anna;
Affiliation
Department of Virology, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100 Puławy, Poland.
Trebas, Pawel;
Affiliation
Artemis One Health Research Foundation, Delft, The Netherlands.
Roose, Jouke M;
Affiliation
Department of Virology, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100 Puławy, Poland.
Zmudzinski, Jan;
GND
1213271622
ORCID
0000-0002-7973-7405
Affiliation
Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
Gerhauser, Ingo;
ORCID
0000-0001-9184-4134
Affiliation
Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
Wohlsein, Peter;
GND
142929565
ORCID
0000-0001-8151-5644
Affiliation
Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany; Center for Systems Neuroscience (ZSN), Hannover, Germany.
Baumgärtner, Wolfgang;
GND
130395951
ORCID
0000-0002-6074-1172
Affiliation
Artemis One Health Research Foundation, Delft, The Netherlands; Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine, Hannover, Germany.
Osterhaus, Albert;
Affiliation
Erasmus Medical Centre Rotterdam, The Netherlands. Electronic address: koraka@viroclinics.com.
Koraka, Penelope

Rabies is a lethal disease in humans and animals, killing approximately 60,000 people every year. Currently, there is no treatment available, except post-exposure prophylaxis (PEP) that can be administered whenever exposure to a rabid animal took place. Here we describe the beneficial effects of a combination treatment initiated at day 4 post infection, containing anti-viral drugs and immune modulators in infected mice. Combination therapy resulted in significant increase in survival time (P < 0.05) and significantly lowers viral RNA in the brain and spinal cord (P < 0.05). Furthermore, treatment influenced markers of pyroptosis and apoptosis and early inflammatory response as measured by the levels of TNF-α. Morphological lesions were absent in rabies virus infected mice with few signs of inflammation. However, these were not significant between the different groups.

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