Stiftung Tierärztliche Hochschule Hannover (TiHo)

Combination drug treatment prolongs survival of experimentally infected mice with silver-haired bat rabies virus

Martina, Byron ORCID; Smreczak, Marcin; Orłowska, Anna GND; Marzec, Anna ORCID; Trebas, Pawel; Roose, Jouke M; Zmudzinski, Jan; Gerhauser, Ingo GND; Wohlsein, Peter ORCID; Baumgärtner, Wolfgang GND; Osterhaus, Albert GND; Koraka, Penelope

Rabies is a lethal disease in humans and animals, killing approximately 60,000 people every year. Currently, there is no treatment available, except post-exposure prophylaxis (PEP) that can be administered whenever exposure to a rabid animal took place. Here we describe the beneficial effects of a combination treatment initiated at day 4 post infection, containing anti-viral drugs and immune modulators in infected mice. Combination therapy resulted in significant increase in survival time (P < 0.05) and significantly lowers viral RNA in the brain and spinal cord (P < 0.05). Furthermore, treatment influenced markers of pyroptosis and apoptosis and early inflammatory response as measured by the levels of TNF-α. Morphological lesions were absent in rabies virus infected mice with few signs of inflammation. However, these were not significant between the different groups.

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Martina, B.E.E., Smreczak, M., Orlowska, A., Marzec, A., Trebas, P., Roose, J.M., Zmudzinski, J., Gerhauser, I., Wohlsein, P., Baumgärtner, W., Osterhaus, A.D.M.E., Koraka, P., 2019. Combination drug treatment prolongs survival of experimentally infected mice with silver-haired bat rabies virus. Vaccine 37, 4736–4742. https://doi.org/10.1016/j.vaccine.2018.05.065
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