Stiftung Tierärztliche Hochschule Hannover (TiHo)

Stem Cell Therapy for Tendon Regeneration: Current Status and Future Directions

Affiliation
, PO Box 1243, 72072, Tübingen, Germany.
Conrad, Sabine;
Affiliation
Tierärztliches Zentrum für Pferde in Kirchheim Altano GmbH, Kirchheim unter Teck, Germany.
Weber, Kathrin;
Affiliation
Tierärztliches Zentrum für Pferde in Kirchheim Altano GmbH, Kirchheim unter Teck, Germany.
Walliser, Ulrich;
GND
124533795
ORCID
0000-0002-3161-9055
Affiliation
Justus-Liebig-University Giessen, Faculty of Veterinary Medicine, Clinic for Horses - Department of Surgery, Giessen, Germany.
Geburek, Florian;
Affiliation
Institute for Anatomy and Cell Biology, Medical Faculty, University of Heidelberg, Heidelberg, Germany. skutella@ana.uni-heidelberg.de.
Skutella, Thomas

In adults the healing tendon generates fibrovascular scar tissue and recovers never histologically, mechanically, and functionally which leads to chronic and to degenerative diseases. In this review, the processes and mechanisms of tendon development and fetal regeneration in comparison to adult defect repair and degeneration are discussed in relation to regenerative therapeutic options. We focused on the application of stem cells, growth factors, transcription factors, and gene therapy in tendon injury therapies in order to intervene the scarring process and to induce functional regeneration of the lesioned tissue. Outlines for future therapeutic approaches for tendon injuries will be provided.

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