Stiftung Tierärztliche Hochschule Hannover (TiHo)TiHo eLib

Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium

ORCID
0000-0002-3828-1421
Affiliation
UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
Raliou, Mariam;
ORCID
0000-0003-3879-6940
Affiliation
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104-Inserm U 964-Université de Strasbourg, Illkirch, France.
Dembélé, Doulaye;
GND
141939281
Affiliation
Immunology Unit, University of Veterinary Medicine, Foundation, Hannover, Hannover, Germany.
Düvel, Anna;
Affiliation
UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
Bolifraud, Philippe;
Affiliation
AgroParisTech, UMR 518 MIA, Paris, France.
Aubert, Julie;
Affiliation
AgroParisTech, UMR 518 MIA, Paris, France.
Mary-Huard, Tristan;
Affiliation
GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Rocha, Dominique;
Affiliation
UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
Piumi, François;
Affiliation
UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
Mockly, Sophie;
GND
129743011
ORCID
0000-0002-3736-4452
Affiliation
University of Veterinary Medicine Hannover, Foundation, Clinic for Cattle, Endocrinology Laboratory, Hannover, Germany.
Heppelmann, Maike;
Affiliation
Zoetis, Zaventem, Belgium.
Dieuzy-Labaye, Isabelle;
Affiliation
Zoetis, Berlin, Germany.
Zieger, Peter;
Affiliation
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Smith, David G. E.;
ORCID
0000-0002-5904-5751
Affiliation
Immunology Unit, University of Veterinary Medicine, Foundation, Hannover, Hannover, Germany.
Schuberth, Hans-Joachim;
ORCID
0000-0001-7902-5558
Affiliation
Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, United Kingdom.
Sheldon, Iain Martin;
Affiliation
UMR BDR, INRA, ENVA, Université Paris Saclay, Jouy en Josas, France.
Sandra, Olivier

Cattle with subclinical endometritis (SCE) are sub-fertile and diagnosing subclinical uterine disease remains a challenge. The hypothesis for this study was that endometrial inflammation is reflected in mRNA expression patterns of peripheral blood leucocytes. Transcriptome profiles were evaluated in healthy cows and in cows with SCE using circulating white blood cells (WBC) and endometrial biopsy samples collected from the same animals at 45-55 days postpartum. Bioinformatic analyses of microarray-based transcriptional data identified gene profiles associated with distinct biological functions in circulating WBC and endometrium. In circulating WBC, SCE promotes a pro-inflammatory environment, whereas functions related to tissue remodeling are also affected in the endometrium. Nineteen differentially expressed genes associated with SCE were common to both circulating WBC and the endometrium. Among these genes, transcript abundance of immune factors C3, C2, LTF, PF4 and TRAPPC13 were up-regulated in SCE cows at 45-55 days postpartum. Moreover, mRNA expression of C3, CXCL8, LTF, TLR2 and TRAPPC13 was temporally regulated during the postpartum period in circulating WBC of healthy cows compared with SCE cows. This observation might indicate an advantageous modulation of the immune system in healthy animals. The transcript abundance of these genes represents a potential source of indicators for postpartum uterine health.

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