Untersuchungen zur Funktion und zu Mechanismen des Ca2+-Transportes im Dünndarm von Saugferkeln

Calcitriol, Duodenum, calcium absorption. - The aim of the present in vitro studies was to further characterize the mechanisms of intestinal Ca2+ absorption in suckling piglets. Simultaneously, Pi transport was examined to get some information about specificity of the effects on Ca2+ transport. Further investigations with weaned piglets were performed to show age related differences. The actin filament inhibitors cytochalasin D and latrunculin B and the microtubule antagonist colchicine as well as an agonist of l-type Ca2+ channels BAY K8644 were used to elucidate the role of cytoskeletal elements and Ca2+ channels for these transport mechanisms. Moreover, acute application of calcitriol should test for the presence of fast response mechanisms of Ca2+ transport in the small intestines of neonatal and weaned piglets.