Untersuchungen zur Signaltransduktion der Lipopolysaccharidvermittelten Aktivierung des Lysozymgens in einer Hühnermyelomonozyten-Zellinie (HD11)
lysozyme gene, signal transduction. - Released from the bacterial surface during the acute bacterial infection, lipopolysaccharides (LPS) play an important role in the pathogenesis and are important virulence factors of Gram-negative infections. LPS cause a large number of pathophysiological reactions like leucopenia, hypotension and the acute-phase response as far as septic shock. LPS activate immunological and inflammatory responses particulary in cells of the immunological system like B-lymphocytes, T-lymphocytes and cells of the mononuclear phagocyte system (monocytes and macrophages). LPS-activated macrophages produce numerous cytokines and antibacterial proteins including lysozyme...
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